Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa (DISCO)

  • Acronym: DISCO
  • Effective start/end date: January 02nd, 2018 September 01st, 2024
  • Funder: NIH
  • Type: Intevation Research

Overview

The DISCO study is a prospective observational cohort study at government-supported HIV clinics in rural South Africa and Uganda, which began in 2019. In the first phase of the study, we enrolled adults with HIV who were switched from first-line antiretroviral therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) to a regimen containing tenofovir, lamivudine, and dolutegravir (TLD) as part of national guidelines. In the second phase of the study, we enrolled treatment-naïve adults with HIV who were initiating ART with TLD. We have followed participants with study visits at enrollment, 24 weeks, and 48 weeks and ≥ 96 weeks. Study procedures include interviews, anthropomorphic measurements, chart review, and collection of blood and urine specimens for retrospective testing, including viral load, drug resistance testing, antiretroviral drug level testing. The study aims to quantify viral suppression rates for adults on TLD, assess regimen tolerability of TLD, and to evaluate the determinants of virologic failure on TLD when it occurs.


Participants

  • Dr. Suzanne M. McCluskey MD (MGH P.I)
  • Dr. Muyindike R. Winnie (MUST P.I)
  • Dr. Mark J. Siedner MD MPH (Co-Investigator)

Partners

NIH


Publications